existence of gonadotrophin in a local system of medicine of animal origin used for contraception

Progesterone and estradiol are responsible for playing a vital role in contraception. The fertilization is prevented mainly either by inhibiting ovulation or by making the mucus of the female genital tract thick and viscid in the present study, the extracted material of "Cyprea moneta shell" has been found to contain a reasonable amount of sex steroids with small amount of gonadotrophins, The concentration of LH and FSH were 0.564 mIU/ml and 0.644 mIU/ml, respectively, as compared to the undetectable amount of gonadotrophin in medicinal plants [Abrus precatorius, Ricinus communis Crotalaria juncea, Acacia arabica and Ficus religiosa]. However, the sex steroid hormones detected in all these medicinal plants were in large amount, causing contraception

Cell cycle and cancer: cycling out of control

Disruption in mechanisms controlling cell proliferation is a hallmark of cancer. In higher eukaryotes, cell cycle progression and cell division is driven by the sequential activation of a family of proteins called cyclin-dependent kinases [Cdks]. Mutations in Cdks or in their molecular modulators have been identified in the vast majority of human tumours. However, ablation of most of these proteins in mice produces only mild phenotypes, suggesting that other compensatory mechanisms exist. Thus unveiling the molecular mechanisms. that control cell cycle is fundamental in understanding the molecular basis of cancer. In this review, we will discuss cell cycle and its regulators and their role in cancer development based on recent findings obtained using genetically modified mice